The leaf of Momordica foetida is used in traditional medicine in many societies to treat a wide range of diseases and disorders which includes but not limited to stomach troubles, as an emetic, as a vermifuge, smallpox, chickenpox, measles, body swellings, oedema, gout, antidotes for venomous stings such as bee stings and also as a pain-killer. The leaves have a bitter taste, but it is prepared and eaten as food in some African countries. Also, the fruits and roots are edible in various countries.

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